Effects of modulation of the cholinergic system activity on the experimental tumor growth and antitumor activity of chlofiden

被引：0
|
作者：
A. N. Pous’kov
N. I. Sharykina
G. P. Pavlovskaya
T. A. Karatsuba
机构：
[1] Academy of Medical Sciences of Ukraine,Institute of Pharmacology and Toxicology
来源：
Neurophysiology | 2000年 / 32卷
关键词：
cholinergic system; cholinesterase; m-cholinoblockers; tumor growth; Pliss lymphosarcoma;
D O I：
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学科分类号：
摘要：
We studied the influence of an anticholinesterase agent, proserine, and an m-cholinoblocker, atropine, on the growth of Pliss lymphosarcoma in rats and on the antitumor activity of a cytotoxic drug, chlofiden. It has been demonstrated that proserine stimulates tumor growth and decreases the antitumor efficacy of chlofiden. Injections of atropine evoked opposite effects: inhibition of the tumor growth and an increase in the, antitumor activity of chlofiden. Possible mechanisms of the above effects are discussed.
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页码：106 / 110
页数：4
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