Dengue virus: a review on advances in detection and trends – from conventional methods to novel biosensors

被引：0
作者：
Reza Eivazzadeh-Keihan
Paria Pashazadeh-Panahi
Tohid Mahmoudi
Karim Khanmohammadi Chenab
Behzad Baradaran
Mahmoud Hashemzaei
Fateme Radinekiyan
Ahad Mokhtarzadeh
Ali Maleki
机构：
[1] Iran University of Science and Technology,Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry
[2] Golestan University of Medical Sciences,Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine
[3] Tabriz University of Medical Sciences,Immunology Research Center
[4] Zabol University of Medical Sciences,Department of Pharmacodynamics and Toxicology, School of Pharmacy
[5] Higher Education Institute of Rab-Rashid,Department of Biotechnology
来源：
Microchimica Acta | 2019年 / 186卷
关键词：
Dengue virus; Biosensor; Biomarker; Serotype; Clinical applications; Immunosensor; Limit of detection;
D O I：
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摘要：
Dengue virus is an important arbovirus infection which transmitted by the Aedes female mosquitoes. The attempt to control and early detection of this infection is a global public health issue at present. Because of the clinical importance of its detection, the main focus of this review is on all of the methods that can offer the new diagnosis strategies. The advantages and disadvantages of reported methods have been discussed comprehensively from different aspects like biomarkers type, sensitivity, accuracy, rate of detection, possibility of commercialization, availability, limit of detection, linear range, simplicity, mechanism of detection, and ability of usage for clinical applications. The optical, electrochemical, microfluidic, enzyme linked immunosorbent assay (ELISA), and smartphone-based biosensors are the main approaches which developed for detection of different biomarkers and serotypes of Dengue virus. Future efforts in miniaturization of these methods open the horizons for development of commercial biosensors for early-diagnosis of Dengue virus infection.
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