Synthesis of substituted 1-[2-(adamantan-1-yl)ethyl]piperidines

被引：0
作者：
V. A. Shadrikova
E. V. Golovin
E. A. Kuznetsova
M. Yu. Rostova
Yu. N. Klimochkin
机构：
[1] Samara State Technical University,
来源：
Russian Journal of Organic Chemistry | 2016年 / 52卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Quaternary 1-[2-(adamantan-1-yl)ethyl]pyridinium bromides were reduced with sodium tetrahydridoborate in ethanol, and hydroarylation of the resulting 1-[2-(adamantan-1-yl)ethyl]-1,2,3,6-tetrahydropyridines with benzene in trifluoromethanesulfonic acid afforded phenylpiperidines with preferentially equatorial orientation of the phenyl substituent.
引用
收藏
页码：1452 / 1462
页数：10
相关论文
共 155 条
[1]  
Taylor R.D.(2014)undefined J. Med. Chem. 57 5845-undefined
[2]  
MacCoss M.(2016)undefined Adv. Heterocycl. Chem. 120 1-undefined
[3]  
Lawson A.D.G.(1975)undefined Pyridine and Its Derivatives, Supplement 4 445-undefined
[4]  
Marson C.M.(2004)undefined Tetrahedron 60 1701-undefined
[5]  
Coutts R.T.(1986)undefined J. Med. Chem. 29 424-undefined
[6]  
Casy A.F.(2001)undefined CNS Drug Rev. 7 25-undefined
[7]  
Buffat M.G.P.(2013)undefined Chem. Rev. 113 3516-undefined
[8]  
Fries D.S.(2015)undefined Russ. Chem. Bull., Int. Ed. 64 1473-undefined
[9]  
de Vries J.(2005)undefined Med. Res. Rev. 25 21-undefined
[10]  
Hazelhoff B.(2011)undefined Eur. J. Med. Chem. 46 1949-undefined
12345678910