Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

被引：2
作者：
Sakamoto A. [1 ]
Yamamoto H. [2 ]
Tanaka K. [1 ]
Matsuda S. [1 ]
Harimaya K. [1 ]
Oda Y. [2 ]
Tsuneyoshi M. [2 ]
Iwamoto Y. [1 ]
机构：
[1] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University
[2] Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
来源：
World Journal of Surgical Oncology | / 4卷 / 1期
关键词：
Chondrosarcoma; Liposarcoma; Angiosarcoma; Malignant Fibrous Histiocytoma; Giant Cell Tumor;
D O I：
10.1186/1477-7819-4-37
中图分类号：
学科分类号：
摘要：
Background: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytomaor osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. Conclusion: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components. © 2006 Sakamoto et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 24 条
  • [1] Roberts A.W., G-CSF: A key regulator of neutrophil production, but that's not all, Growth Factors, 23, 1, pp. 33-41, (2005)
  • [2] Cebon J., Layton J.E., Maher D., Morstyn G., Endogenous haemopoletic growth factors in neutropenia and infection, Br J Haematol, 86, 2, pp. 265-274, (1994)
  • [3] Asano S., Urabe A., Okabe T., Sato N., Kondo Y., Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue, Blood, 49, 5, pp. 845-852, (1977)
  • [4] Kojima K., Nakashima F., Boku A., Muroishi Y., Nakanishi I., Oda Y., Clinicopathological study of involvement of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor in non-lymphohematopoietic malignant tumors accompanied by leukocytosis, Histol Histopathol, 17, 4, pp. 1005-1016, (2002)
  • [5] Kasuga I., Makino S., Kiyokawa H., Katoh H., Ebihara Y., Ohyashiki K., Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma, Cancer, 92, 9, pp. 2399-2405, (2001)
  • [6] Sato T., Omura M., Saito J., Hirasawa A., Kakuta Y., Wakabayashi Y., Nishikawa T., Neutrophilia associated with anaplastic carcinoma of the thyroid: Production of macrophage colony-stimulating factor (M-CSF) and interleukin-6, Thyroid, 10, 12, pp. 1113-1118, (2000)
  • [7] Kyo S., Kanaya T., Takakura M., Inoue M., A case of cervical cancer with aggressive tumor growth: Possible autocrine growth stimulation by G-CSF and 11-6, Gynecol Oncol, 78, 3 PART 1, pp. 383-387, (2000)
  • [8] Mayumi E., Okuno T., Ogawa T., Kurata K., Ishioka H., Hamamoto H., Ishiki K., Maga T., Okamoto T., Yoshida T., Ogura Y., Malignant fibrous histiocytoma of soft tissue producing granulocyte colony-stimulating factor, Intern Med, 40, 6, pp. 536-540, (2001)
  • [9] Dorfman H.D., Czerniak B., Bone Tumors, pp. 353-440, (1998)
  • [10] Sakamoto A., Oda Y., Adachi T., Oshiro Y., Tamiya S., Tanaka K., Matsuda S., Iwamoto Y., Tsuneyoshi M., H-ras oncogene mutation in dedifferentiated chondrosarcoma: Polymerase chain reaction-restriction fragment length polymorphism analysis, Mod Pathol, 14, 4, pp. 343-349, (2001)
123