Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)

被引:0
作者
M. A. Iradyan
N. S. Iradyan
G. M. Stepanyan
F. G. Arsenyan
B. T. Garibdzhanyan
机构
[1] Scientific and Technological Center of Organic and Pharmaceutical Chemistry,Mndzhoyan Institute of Fine Organic Chemistry
[2] National Academy of Sciences of Armenia,undefined
来源
Pharmaceutical Chemistry Journal | 2010年 / 44卷
关键词
dacarbazine; substituted triazenoimidazolcarboxamides; phenyltriazenes; imidazene; antitumor activity; chemotherapy; mechanism of biochemical action;
D O I
暂无
中图分类号
学科分类号
摘要
The physicochemical properties and antitumor activity of dacarbazine, its analogs, and the new alkylating agent imidazene are reviewed. It is shown that the activity of dacarbazine is superior to most of its analogs. Imidazene exhibits an advantage over dacarbazine with respect to both stability and activity and can be used for the treatment of malignant melanoma and sarcoma of soft tissues and in combined chemotherapy.
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页码:175 / 182
页数:7
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