Maintaining genomic stability in pluripotent stem cells

被引：1
作者：
Ping Zheng
机构：
[1] Chinese Academy of Sciences,State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology
[2] Chinese Academy of Sciences,Yunnan Key Laboratory of Animal Reproduction, Kunming Institute of Zoology
来源：
Genome Instability & Disease | 2020年 / 1卷 / 2期
关键词：
Pluripotent stem cells; Genomic stability; Replication stress response; DNA damage response;
D O I：
10.1007/s42764-019-00008-4
中图分类号：
学科分类号：
摘要：
Pluripotent stem cells (PSCs) are capable of generating all types of cells in the body and have promising applications in basic research and cell-based regenerative medicine. Compared to the differentiated cells, PSCs are superior in maintaining genomic stability. However, the underlying molecular mechanisms are far from clear. Here, we summarized the understandings on the molecules and pathways that PSCs specifically utilize to cope with DNA replication-associated stress, to repair DNA damages and to determine cell fates.
引用
收藏
页码：92 / 97
页数：5
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