Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

被引：52
作者：
Chai S. [1 ]
To K.K.W. [2 ]
Lin G. [1 ]
机构：
[1] School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
[2] School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
来源：
Chinese Medicine | / 5卷 / 1期
关键词：
Doxorubicin; Curcumin; Quercetin; Ginsenosides; Panax Ginseng;
D O I：
10.1186/1749-8546-5-26
中图分类号：
学科分类号：
摘要：
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.© 2010 Chai et al; licensee BioMed Central Ltd.
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