Polymorphisms of Tuberculosis Susceptibility Candidate Genes in the Slavonic Population of Siberia: A Pilot Study

被引：0
|
作者：
V. P. Puzyrev
M. B. Freidin
A. A. Rudko
A. K. Strelis
O. V. Kolokolova
机构：
[1] Russian Academy of Medical Sciences,Institute of Medical Genetics, Tomsk Research Center
[2] Siberian State Medical University,undefined
来源：
Molecular Biology | 2002年 / 36卷
关键词：
tuberculosis; susceptibility; candidate gene; polymorphism; p40;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The 469+14 G/C (INT4), 1465-85 G/A, and C274T polymorphisms of NRAMP1 and the A/C polymorphism of IL12 3"UTR were analyzed in ethnic Russians with (N = 58) or without (N = 127) tuberculosis (TB) from Tomsk. On evidence of allele and genotype frequencies, none of the polymorphisms was associated with TB. In the healthy controls, the three NRAMP1 polymorphisms were in linkage disequilibrium with each other (p < 0.001) but not with the IL12 polymorphism. Still the four polymorphisms are potentially informative as concerns their association with TB.
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页码：634 / 636
页数：2
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