Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents

被引：0
作者：
Azza T. Taher
Nadia A. Khalil
Eman M. Ahmed
机构：
[1] Cairo University,Department of Organic Chemistry, Faculty of Pharmacy
来源：
Archives of Pharmacal Research | 2011年 / 34卷
关键词：
Isatin; Benzimidazole; Thiazoline; Breast cancer; Anticancer activity;
D O I：
暂无
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学科分类号：
摘要：
A series of new isatin-thiazoline 3a–h and isatin-benzimidazole 4a–h derivatives were synthesized via condensation of isatin Mannich bases 2a–h with either 2-aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were characterized by spectral data. The anti-breast cancer activity of some of the synthesized compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compounds 4b, 4d and 4g possess significant antiproliferative activity against MCF-7 cells.
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页码：1615 / 1621
页数：6
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[1]  
Bramson H. N.(2001)Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis J. Med. Chem. 44 4339-4358
[2]  
Corona J.(2002)Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis Cancer Lett. 183 53-60
[3]  
Davis S. T.(2007) and Bioorg. Med. Chem. Lett. 17 5897-5901
[4]  
Dickerson S. H.(2008)Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4 Bioorg. Med. Chem. 16 3118-3124
[5]  
Edelstein M.(2009)N-phenethyl and N-naphthylmethyl isatins and analogues as Curr. Cancer Drug Targets 9 298-306
[6]  
Frye S. V.(2006) cytotoxic agents J. Clin. Oncol. 24 16-24
[7]  
Gampe R. T.(2005)Design of new drug molecules to be used in reversing multidrug resistance in cancer cells Acta Pharm. 55 27-46
[8]  
Harris P. A.(2006)Activity of SU11248, a multi-targeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma Bioorg. Med. Chem. 14 7324-7332
[9]  
Hassell A.(2008)Biological activities of isatin and its derivatives Semin. Diagn. Pathol. 25 245-261
[10]  
Holmes W. D.(2006)Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles Bioorg. Med. Chem. 14 6475-6485
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