Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

被引:0
作者
S Mitsunaga
M Ikeda
S Shimizu
I Ohno
J Furuse
M Inagaki
S Higashi
H Kato
K Terao
A Ochiai
机构
[1] National Cancer Center Hospital East,Division of Hepatobiliary and Pancreatic Oncology
[2] Research Center for Innovative Oncology,Pathology Division
[3] National Cancer Center Hospital East,Department of Medical Oncology
[4] Kyorin University School of Medicine,Primary Lifecycle Management Department
[5] Center for Suicide Prevention,Clinical Research Planning Department
[6] National Institute of Mental Health,undefined
[7] National Center of Neurology and Psychiatry,undefined
[8] Chugai Pharmaceutical Co.,undefined
[9] Ltd.,undefined
[10] Chugai Pharmaceutical Co.,undefined
[11] Ltd.,undefined
来源
British Journal of Cancer | 2013年 / 108卷
关键词
pancreatic cancer; gemcitabine; interleukin-1; interleukin-6; chemotherapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2063 / 2069
页数:6
相关论文
共 268 条
[1]  
Aggarwal BB(2009)Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe Clin Cancer Res 15 425-430
[2]  
Vijayalekshmi RV(2008)Mononuclear cell-derived interleukin-1beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2 Surgery 144 57-65
[3]  
Sung B(2002)Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines Cancer Res 62 910-916
[4]  
Angst E(1999)Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer Clin Sci (Lond) 96 83-87
[5]  
Reber HA(2006)Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival Cancer Immunol Immunother 55 684-698
[6]  
Hines OJ(2010)Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev 29 317-329
[7]  
Eibl G(2010)Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer Clin Cancer Res 16 3028-3034
[8]  
Arlt A(2004)Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis Cancer 101 2727-2736
[9]  
Vorndamm J(1998)Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid J Clin Endocrinol Metab 83 847-850
[10]  
Müerköster S(1998)Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines Biochem Biophys Res Commun 157 271-277