Mechanisms of the Effects of Adrenocorticotropic Hormone on Pain Sensitivity in Rats

被引：10

作者：

A. I. Bogdanov

N. I. Yarushkina

机构：

[1] Department of Endocrine Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

来源：

Neuroscience and Behavioral Physiology | 2003年 / 33卷 / 8期

关键词：

ACTH; Corticosterone; Opiate receptors; Pain sensitivity; Rats;

D O I：

10.1023/A:1025149432058

中图分类号：

学科分类号：

摘要：

Experiments on anaesthetized male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain sensitivity. Systemic administration of ACTH to animals with normal hormone production induced rapidly developing (starting at 3 min) and prolonged (30 min) increases in pain response thresholds. Blockade of opiate receptors led to suppression of the initial stage of the analgesic effect of ACTH: the response was seen only from 15 to 30 min. In animals with deficient glucocorticoid production, the duration of the analgesic action of ACTH decreased to 15 min. Analgesia was completely eliminated by the combination of suppression of glucocorticoid production and blockade of opiate receptors. The analgesic effect of ACTH was mediated by two mechanisms: 1) a rapidly-acting (from 3 to 15 min) mechanism associated with opiate receptors and not related to glucocorticoids, and 2) a delayed (from 15 to 30 min) mechanism associated with glucocorticoids but not opiate receptors.

引用

页码：795 / 798

页数：3

共 19 条

[1]

Bogdanov A.I., Yarushkina N.I., Relationship between analgesia and corticosteroid levels in rats, Ros. Fiziol. Zh. Im. I. M. Sechenova, 85, 3, pp. 466-468, (1999)

[2]

Bogdanov A.I., Yarushkina N.I., The effects of ACTH on pain sensitivity in rats, Byull. Éksperim. Biol. Med., 131, 3, pp. 260-262, (2001)

[3]

Filaretov A.A., Bogdanov A.I., Yarushkina N.I., Stress-evoked analgesia. The role of hormones from the hypophyseal-adrenocortical system, Ros. Fiziol. Zh. im. I. M. Sechenova, 81, pp. 40-46, (1995)

[4]

Yarushkina N.I., Bogdanov A.I., The role of corticosteroids in supporting the analgesic effect induced by stimulation of the central gray matter of the midbrain, Ros. Fiziol. Zh. im. I. M. Sechenova, 84, 7, pp. 642-650, (1998)

[5]

Bodnar R.J., Kelly D.D., Splaggia A., Ehrenberg C., Glusman M., Dose-dependent reductions by naloxone of analgesia induced by cold-water stress, Pharmacol. Biochem. Behav., 8, pp. 667-672, (1978)

[6]

Chakour M.C., Gibson S.J., Bradbeer M., Helm R.D., The effect of age on a delta and C-fiber thermal pain perception, Pain, 64, 1, pp. 143-152, (1996)

[7]

Filaretova L.P., Filaretov A.A., Makara G.B., Corticosterone rise inhibits stress-induced gastric erosions in rats, Amer. J. Physiol., 274, 34, (1998)

[8]

Frischknecht H.R., Siegfried B., Emergence and development of stress-induced analgesia and concomitant behavioral changes in mice exposed to social conflict, Physiol. Behav., 44, 3, pp. 383-388, (1988)

[9]

Kelsey J.E., Hoerman W.A., Kimball L., Radack L.S., Carter M.V., Arcuate nucleus lesions reduce opioid stress-induced analgesia (SIA) and enhance non-opioid SIA in rats, Brain. Res., 386, pp. 278-290, (1986)

[10]

Hayes R.L., Bennett P.G., Newlon P.G., Mayer D.J., Behavioral and physiological studies of non-narcotic analgesia in rat elicited by certain environmental stimuli, Brain Res., 386, pp. 278-290, (1986)

← 1 2 →