Topical agents for the treatment of chronic pain

被引：6
作者：
Argoff C.E. [1 ]
机构：
[1] North Shore University Hospital, NYU School of Medicine, Cohn Pain Management Center, Bethpage, NY 11714
来源：
Current Pain and Headache Reports | 2006年 / 10卷 / 1期
关键词：
Neuropathic Pain; Capsaicin; Postherpetic Neuralgia; Glucosamine Sulfate; Topical Capsaicin;
D O I：
10.1007/s11916-006-0004-4
中图分类号：
学科分类号：
摘要：
Unlike systemic analgesics, topical analgesics exert their analgesic activity locally and without significant systemic absorption. This is in contrast to transdermal analgesics, which require systemic absorption for clinical benefit. The mechanism of action of a particular topical analgesic is unique to the specific medication being used as a topical analgesic. Topical analgesics have been studied in an increasing number of painful clinical conditions, and the results of some of these studies are summarized in this article. The potential role of topical analgesics acting peripherally in affecting the central processing of pain as well as painful states considered to be "central," not "peripheral," also are reviewed. Copyright © 2006 by Current Science Inc.
引用
收藏
页码：11 / 19
页数：8
相关论文
共 80 条
[1]  
Argoff C.E., New analgesics for neuropathic pain: The lidocaine patch, Clin J Pain, 16, SUPPL., (2000)
[2]  
Argoff C.E., Topical treatments for pain, Curr Pain Headache Rep, 8, pp. 261-267, (2004)
[3]  
Argoff C.E., Targeted topical peripheral analgesics in the management of pain, Curr Pain Headache Rep, 7, pp. 34-38, (2002)
[4]  
Galer B.S., Topical medications, Bonica's Management of Pain, pp. 1736-1741, (2001)
[5]  
Gammaitoni A.R., Alvarez N.A., 24-hour application of the lidocaine patch 5% for 3 consecutive days is safe and well tolerated in healthy adult men and women, (2002)
[6]  
Argoff C., Nicholson B., Moskowitz M., Et al., Effectiveness of lidocaine patch 5% (Lidoderm®) in the treatment of low back pain, (2002)
[7]  
Watson C.P., Topical capsaicin as an adjuvant analgesic, J Pain Symptom Manage, 9, pp. 425-433, (1994)
[8]  
Gammaitoni A.R., Davis M.W., Pharmacokinetics and tolerability of lidocaine 5% patch with extended dosing, Ann Pharmacother, 36, pp. 236-240, (2002)
[9]  
Ness T.J., Jones L., Smith H., Use of compounded topical analgesics- Results of an Internet survey, Reg Anesth Pain Med, 27, pp. 309-312, (2002)
[10]  
Sawynok J., Topical and peripherally acting analgesics, Pharmacol Rev, 55, pp. 1-20, (2003)
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