Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents

[1] Horton JD(2007)Molecular biology of PCSK9: its role in LDL metabolism Trends Biochem Sci 32 71-77

[2] Cohen JC(2008)Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease Endocr Metab Immune Disord Drug Targets 8 238-243

[3] Hobbs HH(2009)PCSK9: a convertase that coordinates LDL catabolism J Lipid Res 50 172-177

[4] Cao G(2009)PCSK9 as a therapeutic target of dyslipidemia Expert Opin Ther Targets 13 19-28

[5] Qian YW(2006)PCSK9: a promising therapeutic target for dyslipidemias Trends Endocrinol Metab 17 79-81

[6] Kowala MC(2009)The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis J Intern Med 266 507-519

[7] Konrad RJ(2003)The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation Proc Natl Acad Sci USA 100 928-33

[8] Horton JD(2003)Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nat Genet 34 154-156

[9] Cohen JC(2004)Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype Proc Natl Acad Sci USA 101 7100-7105

[10] Hobbs HH(2009)Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells J Biol Chem 284 10561-10570

[1] Horton JD(2007)Molecular biology of PCSK9: its role in LDL metabolism Trends Biochem Sci 32 71-77

[2] Cohen JC(2008)Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease Endocr Metab Immune Disord Drug Targets 8 238-243

[3] Hobbs HH(2009)PCSK9: a convertase that coordinates LDL catabolism J Lipid Res 50 172-177

[4] Cao G(2009)PCSK9 as a therapeutic target of dyslipidemia Expert Opin Ther Targets 13 19-28

[5] Qian YW(2006)PCSK9: a promising therapeutic target for dyslipidemias Trends Endocrinol Metab 17 79-81

[6] Kowala MC(2009)The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis J Intern Med 266 507-519

[7] Konrad RJ(2003)The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation Proc Natl Acad Sci USA 100 928-33

[8] Horton JD(2003)Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nat Genet 34 154-156

[9] Cohen JC(2004)Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype Proc Natl Acad Sci USA 101 7100-7105

[10] Hobbs HH(2009)Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells J Biol Chem 284 10561-10570