The role of glycine in regulated cell death

被引：0
作者：
Joel M. Weinberg
Anja Bienholz
M. A. Venkatachalam
机构：
[1] Veterans Affairs Ann Arbor Healthcare System and University of Michigan,Division of Nephrology, Department of Internal Medicine
[2] University Duisburg-Essen,Department of Nephrology
[3] University of Texas Health Science Center,Department of Pathology
来源：
Cellular and Molecular Life Sciences | 2016年 / 73卷
关键词：
Glycine; Cytoprotection; Cell death;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The cytoprotective effects of glycine against cell death have been recognized for over 28 years. They are expressed in multiple cell types and injury settings that lead to necrosis, but are still not widely appreciated or considered in the conceptualization of cell death pathways. In this paper, we review the available data on the expression of this phenomenon, its relationship to major pathophysiologic pathways that lead to cell death and immunomodulatory effects, the hypothesis that it involves suppression by glycine of the development of a hydrophilic death channel of molecular dimensions in the plasma membrane, and evidence for its impact on disease processes in vivo.
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页码：2285 / 2308
页数：23
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