Hypoxia-induced nitric oxide protects chondrocytes from damage by hydrogen peroxide

被引：0

作者：

T. Matsushita

K. Fukuda

K. Yamazaki

N. Yamamoto

S. Asada

K. Yoshida

H. Munakata

C. Hamanishi

机构：

[1] Kinki University School of Medicine,Department of Orthopaedic Surgery

[2] Kinki University School of Medicine,Department of Biochemistry

来源：

Inflammation Research | 2004年 / 53卷

关键词：

Chondrocyte; Apoptosis; Hypoxia; Nitric oxide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective:Because articular cartilage has no vascular supply, chondrocytes are hypoxic under normal physiological conditions. Nitric oxide (NO) plays an important role in chondrocyte damage, such as apoptosis. Although oxygen stress with hydrogen peroxide was found to cause chondrocyte damage, these data were obtained under normoxic (21% O2) conditions. We investigated the effects of hypoxia on hydrogen peroxide-induced chondrocyte damage

引用

页码：344 / 350

页数：6