Synthesis and Antiviral Activity of Betulonic Acid Amides and Conjugates with Amino Acids

被引：0
|
作者：
O. B. Flekhter
E. I. Boreko
L. R. Nigmatullina
E. V. Tret'yakova
N. I. Pavlova
L. A. Baltina
S. N. Nikolaeva
O. V. Savinova
V. F. Eremin
F. Z. Galin
G. A. Tolstikov
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Scientific Center
[2] State Research Institute of Epidemiology and Microbiology,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2004年 / 30卷
关键词：
amides; antiviral activity; betulonic acid; lupane triterpenoids; peptides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Betulonic acid amides with aliphatic and heterocyclic amines and with L-amino acids were synthesized by the acid chloride method. Betulonic acid amide and L-methionine derivatives of betulonic acid and its 3-oxime effectively inhibit the influenza A virus. Betulonic acid octadecylamide is active against the herpes simplex Type 1 virus. The conjugate of betulonic acid 3-oxime with L-methionine is also active toward HIV-1. The tested compounds mainly show no activity toward the ECHO6 virus, which is devoid of a coat.
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页码：80 / 88
页数：8
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