Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage

被引：0
作者：
V. V. Zabrodina
O. V. Shreder
E. D. Shreder
A. D. Durnev
机构：
[1] V. V. Zakusov Research Institute of Pharmacology,
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
streptozotocin; diabetes; afobazole; betaine; DNA comet assay;
D O I：
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学科分类号：
摘要：
Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes.
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页码：359 / 366
页数：7
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  • [9] Zabrodina VV(undefined)undefined undefined undefined undefined-undefined
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