Multiple Orthokeratinized Odontogenic Cysts: A Case Report

被引：9

作者：

Cheng Y.-S.L. ^{[1
]}

Liang H. ^{[1
]}

Wright J. ^{[1
]}

Teenier T. ^{[2
]}

机构：

[1] Diagnostic Sciences, Texas A&M University-Baylor College of Dentistry, 3302 Gaston Ave, Dallas, 75246, TX

[2] Oral and Maxillofacial Surgery Private Practice, 5402 Holly Road, Suite 302, Building 3, Corpus Christi, 78411, TX

来源：

Head and Neck Pathology | 2015年 / 9卷 / 1期

关键词：

Nevoid basal cell carcinoma syndrome; Orthokeratinized odontogenic cyst; Orthokeratinized odontogenic keratocyst; PTCH;

D O I：

10.1007/s12105-014-0545-5

中图分类号：

学科分类号：

摘要：

The purpose of this report is to document the clinical, radiographic, pathological and molecular findings of the first case of multiple orthokeratinized odontogenic cysts (OOCs). Multiple odontogenic keratocysts are one of the major features of nevoid basal cell carcinoma syndrome (NBCCS), and loss of heterozygosity in the PTCH gene, the culprit gene for NBCCS, has recently been found in sporadic OOC cases. Therefore, in this presenting case, we also investigated the possibility that this patient might also have NBCCS, by comparing the available clinical information and the molecular findings of this case to the diagnostic criteria for NBCCS (as proposed by the First International Colloquium on NBCCS in 2011). However, this patient with multiple OOCs showed no evidence of having NBCCS. This conclusion supports the findings from previous case series based on sporadic cases that OOC does not appear to be associated with NBCCS. © 2014, Springer Science+Business Media New York.

引用

页码：153 / 157

页数：4

共 27 条

[1]

Wright J.M., The odontogenic keratocyst: orthokeratinized variant, Oral Surg Oral Med Oral Pathol, 51, 6, pp. 609-618, (1981)

[2]

Li T.J., Kitano M., Chen X.M., Et al., Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases, Histopathology, 32, 3, pp. 242-251, (1998)

[3]

Dong Q., Pan S., Sun L.S., Li T.J., Orthokeratinized odontogenic cyst: a clinicopathologic study of 61 cases, Arch Pathol Lab Med, 134, 2, pp. 271-275, (2010)

[4]

Crowley T.E., Kaugars G.E., Gunsolley J.C., Odontogenic keratocysts: a clinical and histologic comparison of the parakeratin and orthokeratin variants, J Oral Maxillofac Surg, 50, 1, pp. 22-26, (1992)

[5]

Neville B.W., Damm D.D., Allen C.M., Bouquot J.E., Orthokeratinized odontogenic cyst, Oral and maxillofacial pathology, pp. 687-688, (2009)

[6]

Bree A.F., Shah M.R., Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS), Am J Med Genet A, 155A, 9, pp. 2091-2097, (2011)

[7]

Diniz M.G., Galvao C.F., Macedo P.S., Gomes C.C., Gomez R.S., Evidence of loss of heterozygosity of the PTCH gene in orthokeratinized odontogenic cyst, J Oral Pathol Med, 40, 3, pp. 277-280, (2011)

[8]

Macdonald-Jankowski D.S., Orthokeratinized odontogenic cyst: a systematic review, Dentomaxillofac Radiol, 39, 8, pp. 455-467, (2010)

[9]

Kasat V.O., Saluja H., Kalburge J.V., Et al., Multiple bilateral supernumerary mandibular premolars in a non-syndromic patient with associated orthokeratised odontogenic cyst—a case report and review of literature, Contemp Clin Dent, 3, pp. 248-252, (2012)

[10]

Aragaki T., Michi Y., Katsube K., Et al., Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst, Hum Pathol, 41, 12, pp. 1718-1725, (2010)

← 1 2 3 →