Melatonin in Chronic Pain Syndromes

被引：1

作者：

Kurganova Y.M. ^{[1
]}

Danilov A.B. ^{[1
]}

机构：

[1] First Sechenov Moscow Medical University, Moscow

来源：

Neuroscience and Behavioral Physiology | 2017年 / 47卷 / 7期

关键词：

chronic pain; circadian rhythms; melatonin; spinal pain;

D O I：

10.1007/s11055-017-0472-5

中图分类号：

学科分类号：

摘要：

Melatonin is a neurohormone synthesized in the pineal gland and extrapineal structures and has a number of functions, including chronobiotic, antioxidant, oncostatic, immunomodulatory, normothymic, and anxiolytic actions, the abilities to affect the cardiovascular system and the gastrointestinal tract and take part in reproductive functions, and a role in regulating substance metabolism and body weight. In addition, recent studies have demonstrated the efficacy of melatonin in relation to pain syndromes. We present here a review of studies of the use of melatonin in fibromyalgia, headaches, irritable bowel syndrome, chronic back pain, and rheumatoid arthritis. The possible mechanisms mediating the analgesic properties of melatonin are discussed. On the one hand, normalization of circadian rhythms, which are inevitably deranged by chronic pain syndromes, improves sleep and activates the intrinsic adaptive potential of melatonin; on the other, data have been obtained showing that melatonin has independent analgesic influences mediated via melatonin receptors and various neurotransmitter systems. © 2017, Springer Science+Business Media, LLC.

引用

页码：806 / 812

页数：6

共 45 条

[1]

Lucas R.J., Lall G.S., Allen A.E., Brown T.M., How rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock, Prog. Brain Res., 199, pp. 1-18, (2012)

[2]

Srinivasan V., Pandi-Perumal S.R., Maestroni G.J., Et al., Role of melatonin in neurodegenerative diseases, Neurotox Res., 7, pp. 293-318, (2005)

[3]

Pandi-Perumal S.R., Srinivasan V., Maestroni G.J.M., Et al., Melatonin: Nature’s most versatile biological signal?, FEBS J., 273, pp. 2813-2838, (2006)

[4]

Yongliang L., Hongwen H., Fang H., Melatonin in pain modulation: analgesic or proalgesic?, Pain Stud. Treat., 2, pp. 50-55, (2014)

[5]

Golombek D.A., Escolar E., Burin L.J., Et al., Time dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism, Eur. J. Pharmacol., 194, pp. 25-30, (1991)

[6]

Yu C.X., Zhu B., Xu S.F., Et al., The analgesic effects of peripheral and central administration of melatonin in rats, Eur. J. Pharmacol., 403, pp. 49-53, (2000)

[7]

El-Shenawy S.M., Abdel-Salam O.M., Baiuomy A.R., Et al., Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat, Pharmacol. Res., 46, 3, pp. 235-243, (2002)

[8]

Esposito E., Paterniti I., Mazzon E., Et al., Melatonin reduces hyperalgesia associated with inflammation, J. Pineal Res., 49, 4, pp. 321-331, (2010)

[9]

Mantovani M., Pertile R., Calixto J.B., Et al., Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway, Neurosci Lett., 343, 1, pp. 1-4, (2003)

[10]

Pain, (2004)

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