Piezo2 is the principal mechanotransduction channel for proprioception

被引：0
|
作者：
Seung-Hyun Woo
Viktor Lukacs
Joriene C de Nooij
Dasha Zaytseva
Connor R Criddle
Allain Francisco
Thomas M Jessell
Katherine A Wilkinson
Ardem Patapoutian
机构：
[1] Howard Hughes Medical Institute,Department of Neuroscience
[2] Molecular and Cellular Neuroscience,Department of Biochemistry and Molecular Biophysics
[3] Dorris Neuroscience Center,Department of Biological Sciences
[4] The Scripps Research Institute,undefined
[5] Howard Hughes Medical Institute,undefined
[6] Columbia University,undefined
[7] Howard Hughes Medical Institute,undefined
[8] Columbia University,undefined
[9] San José State University,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
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摘要：
Proprioception, the sense of body and limb position, begins in nerve cells called proprioceptors that are activated by muscle or joint stretch. The molecular mechanism of mechanotransduction in mammalian proprioceptors is unknown. The authors show that the mechanically activated cation channel Piezo2 is the principal mechanotransducer in murine proprioceptors.
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页码：1756 / 1762
页数：6
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