Genome-wide association studies establish that human intelligence is highly heritable and polygenic

被引：0
作者：
G Davies
A Tenesa
A Payton
J Yang
S E Harris
D Liewald
X Ke
S Le Hellard
A Christoforou
M Luciano
K McGhee
L Lopez
A J Gow
J Corley
P Redmond
H C Fox
P Haggarty
L J Whalley
G McNeill
M E Goddard
T Espeseth
A J Lundervold
I Reinvang
A Pickles
V M Steen
W Ollier
D J Porteous
M Horan
J M Starr
N Pendleton
P M Visscher
I J Deary
机构：
[1] University of Edinburgh,Department of Psychology
[2] Institute of Genetics and Molecular Medicine,Department of Clinical Medicine
[3] MRC Human Genetics Unit,Department of Food and Agricultural Systems
[4] Western General Hospital,Department of Psychology
[5] University of Edinburgh,Department of Biological and Medical Psychology
[6] The Roslin Institute,Department of Medicine
[7] Royal (Dick) School of Veterinary Studies,undefined
[8] University of Edinburgh,undefined
[9] Centre for Integrated Genomic Medical Research,undefined
[10] University of Manchester,undefined
[11] Queensland Institute of Medical Research,undefined
[12] Medical Genetics Section,undefined
[13] University of Edinburgh Molecular Medicine Centre,undefined
[14] Institute of Genetics and Molecular Medicine,undefined
[15] Western General Hospital,undefined
[16] Centre for Cognitive Ageing and Cognitive Epidemiology,undefined
[17] University of Edinburgh,undefined
[18] Institute of Child Health,undefined
[19] University College London,undefined
[20] Dr Einar Martens Research Group for Biological Psychiatry,undefined
[21] University of Bergen,undefined
[22] Institute of Applied Health Sciences,undefined
[23] University of Aberdeen,undefined
[24] Nutrition and Epigenetics Group,undefined
[25] Rowett Institute of Nutrition and Health,undefined
[26] University of Aberdeen,undefined
[27] University of Melbourne,undefined
[28] Biosciences Research Division,undefined
[29] Department of Primary Industries,undefined
[30] Center for the Study of Human Cognition,undefined
[31] University of Oslo,undefined
[32] University of Bergen,undefined
[33] School of Epidemiology and Health Science,undefined
[34] University of Manchester,undefined
[35] Center for Medical Genetics and Molecular Medicine,undefined
[36] Haukeland University Hospital,undefined
[37] School of Community-Based Medicine,undefined
[38] Neurodegeneration Research Group,undefined
[39] University of Manchester,undefined
[40] Salford Royal NHS Foundation Trust,undefined
[41] Geriatric Medicine Unit,undefined
[42] University of Edinburgh,undefined
[43] Royal Victoria Hospital,undefined
来源：
Molecular Psychiatry | 2011年 / 16卷
关键词：
genetics; GWAS; intelligence; quantitative trait;
D O I：
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中图分类号：
学科分类号：
摘要：
General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in intelligence are strongly associated with many important life outcomes, including educational and occupational attainments, income, health and lifespan. Data from twin and family studies are consistent with a high heritability of intelligence, but this inference has been controversial. We conducted a genome-wide analysis of 3511 unrelated adults with data on 549 692 single nucleotide polymorphisms (SNPs) and detailed phenotypes on cognitive traits. We estimate that 40% of the variation in crystallized-type intelligence and 51% of the variation in fluid-type intelligence between individuals is accounted for by linkage disequilibrium between genotyped common SNP markers and unknown causal variants. These estimates provide lower bounds for the narrow-sense heritability of the traits. We partitioned genetic variation on individual chromosomes and found that, on average, longer chromosomes explain more variation. Finally, using just SNP data we predicted ∼1% of the variance of crystallized and fluid cognitive phenotypes in an independent sample (P=0.009 and 0.028, respectively). Our results unequivocally confirm that a substantial proportion of individual differences in human intelligence is due to genetic variation, and are consistent with many genes of small effects underlying the additive genetic influences on intelligence.
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页码：996 / 1005
页数：9
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