Changes in hippocampal and neocortical neurons in rats in different regimes of hypobaric hypoxia

被引：0
作者：
Churilova A.V. [1 ]
Glushchenko T.S. [1 ]
Samoilov M.O. [1 ]
机构：
[1] Laboratory for the Regulation of Brain Neuron Function, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg
来源：
Neuroscience and Behavioral Physiology | 2013年 / 43卷 / 1期
基金：
俄罗斯基础研究基金会;
关键词：
hippocampus; hypobaric hypoxia; neocortex; preconditioning;
D O I：
10.1007/s11055-012-9682-z
中图分类号：
学科分类号：
摘要：
Hypobaric hypoxia can have both harmful and adaptogenic influences on the structural-functional characteristics of brain neurons. Experiments on rats (n = 30) addressed morphological changes in hippocampal and neocortical neurons in different regimes of hypobaric hypoxia. Severe hypoxia (barochamber pressure 180 mmHg) was found to induce structural damage to neurons in the frontoparietal neocortex, as well as in the dorsal and ventral areas of the hippocampus, at three days. Preconditioning with moderate hypobaric hypoxia (barochamber pressure 360 mmHg) had different influences on the morphological characteristics of neurons in rats subjected to severe hypoxia. Repeated (three or six times) sessions of preconditioning prevented structural damage to neurons induced by severe hypoxia. In contrast, single sessions of preconditioning did not have this effect. © 2012 Springer Science+Business Media New York.
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页码：1 / 5
页数：4
相关论文
共 15 条
  • [1] Vataeva L.A., Tyulkova E.I., Samoilov M.O., Effects of prior moderate hypoxia on impairments to the acquisition and reproduction of a conditioned reflex passive avoidance reaction induced by severe hypobaric hypoxia in rats, Zh. Vyssh. Nerv. Deyat., 54, 6, pp. 795-801, (2004)
  • [2] Rybnikova E.A., Khozhai L.I., Tyulkova E.I., Et al., Effects of hypobaric hypoxia on the expression of early gene proteins and structural changes to brain neurons: The correcting effect of preconditioning, Morfologiya, 125, 2, pp. 10-15, (2004)
  • [3] Samoilov M.O., The Brain and Adaptation, (1999)
  • [4] Samoilov M.O., Rybnikova E.A., Sitnik N.A., Et al., Preconditioning modifies the activity of mitogen-activated protein kinase and transcription factor c-jun in the rat hippocampus after severe hypobaric hypoxia, Neirokhimiya, 24, 1, pp. 52-59, (2007)
  • [5] Samoilov M.O., Rybnikova R.A., Tyulkova E.I., Et al., Effects of hypobaric hypoxia on behavioral reactions and the expression of early genes in the rat brain: Correcting effects of preconditioning, Dokl. Ros. Akad. Nauk., 381, 1, pp. 1-3, (2001)
  • [6] Samoilov M.O., Sitnik N.A., Rybnikova E.A., Et al., Characteristics of the expression of the pro- and antiapoptotic proteins Bax and Bcl-2 in rat brain neurons in response to severe hypobaric hypoxia: The correcting effect of hypoxic preconditioning, Dokl. Ros. Akad. Nauk., 403, 4, pp. 1-3, (2005)
  • [7] Stroev S.A., Samoilov M.O., Endogenous Antioxidants and the Hypoxic Tolerance of the Brain [In Russian], (2006)
  • [8] Charciaut-Marlangue C., Ben-Ari Y., A cautionary note on the use of the TUNEL stain to determine apoptosis, Neuroreport, 7, 1, pp. 61-64, (1995)
  • [9] Kadar T., Dachir S., Shukitt-Hale B., Levy A., Sub-regional hippocampal vulnerability in various animal models leading to cognitive dysfunction, J. Neural Transm. Gen. Soc., 105, 8-9, pp. 987-1004, (1998)
  • [10] Kirino T., Tsujita Y., Tamura A., Induced tolerance to ischemia in gerbil hippocampal neurons, J. Cereb. Blood Flow Metab., 11, 2, pp. 299-307, (1991)
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