Direct neuronal effects of statins

被引：2

作者：

Bösel J. ^{[1
,2
]}

Endres M. ^{[1
]}

机构：

[1] Neurologische Klinik und Poliklinik, Charité - Universitätsmedizin Berlin

[2] Neurologische Klinik und Poliklinik, Charité - Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin

来源：

Der Nervenarzt | 2006年 / 77卷 / 3期

关键词：

Blood-brain barrier; HMG-CoA reductase inhibitors; Pleiotropic effects; Statins;

D O I：

10.1007/s00115-005-1963-0

中图分类号：

学科分类号：

摘要：

Statins, i.e. HMG-CoA reductase inhibitors, reduce the risk of stroke and may have therapeutic potential for other neurologic diseases, including multiple sclerosis and Alzheimer's disease. In addition to lowering cholesterol levels, statins exert a number of cholesterol-independent (pleiotropic) effects. While endothelial, anti-thrombotic, anti-inflammatory, and immunomodulatory, i.e. peripheral, effects of statins are well known, little is known about the direct effects on neurons. This may be of clinical relevance because some statins are able to cross the blood-brain barrier. Recent experimental studies demonstrate that statins reduce the activity of neuronal glutamate receptors and protect neurons from excitotoxic insults. At higher doses, however, statins may also inhibit neurite sprouting and even induce neuronal apoptosis. © Springer Medizin Verlag 2005.

引用

页码：289 / 293

页数：4

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