Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

被引：0

作者：

Jimmy Z Liu

Suzanne van Sommeren

Hailiang Huang

Siew C Ng

Rudi Alberts

Atsushi Takahashi

Stephan Ripke

James C Lee

Luke Jostins

Tejas Shah

Shifteh Abedian

Jae Hee Cheon

Judy Cho

Naser E Daryani

Lude Franke

Yuta Fuyuno

Ailsa Hart

Ramesh C Juyal

Garima Juyal

Won Ho Kim

Andrew P Morris

Hossein Poustchi

William G Newman

Vandana Midha

Timothy R Orchard

Homayon Vahedi

Ajit Sood

Joseph J Y Sung

Reza Malekzadeh

Harm-Jan Westra

Keiko Yamazaki

Suk-Kyun Yang

Jeffrey C Barrett

Andre Franke

Behrooz Z Alizadeh

Miles Parkes

Thelma B K

Mark J Daly

Michiaki Kubo

Carl A Anderson

Rinse K Weersma

机构：

[1] Wellcome Trust Sanger Institute,Department of Gastroenterology and Hepatology

[2] University of Groningen,Department of Genetics

[3] University Medical Center Groningen,Department of Medicine and Therapeutics

[4] University of Groningen,Department of Gastroenterology and Hepatology

[5] University Medical Center Groningen,Department of Gastroenterology

[6] Analytic and Translational Genetics Unit,Department of Genetics

[7] Massachusetts General Hospital,Department of Biostatistics

[8] Harvard Medical School,Department of Medicine

[9] Institute of Digestive Disease,Department of Gastroenterology and Hepatology

[10] LKS Institute of Health Science,Department of Gastroenterology and Hepatology

[11] State Key Laboratory of Digestive Disease,Department of Epidemiology

[12] Chinese University of Hong Kong,undefined

[13] Laboratory for Statistical Analysis,undefined

[14] Center for Integrative Medical Sciences,undefined

[15] RIKEN,undefined

[16] Inflammatory Bowel Disease Research Group,undefined

[17] Addenbrooke's Hospital,undefined

[18] Wellcome Trust Centre for Human Genetics,undefined

[19] University of Oxford,undefined

[20] Digestive Disease Research Institute,undefined

[21] Shariati Hospital,undefined

[22] Yonsei University College of Medicine,undefined

[23] Icahn School of Medicine,undefined

[24] Mount Sinai Hospital,undefined

[25] Emam Hospital,undefined

[26] Laboratory for Genotyping Development,undefined

[27] Center for Integrative Medical Sciences,undefined

[28] RIKEN,undefined

[29] Inflammatory Bowel Disease Unit,undefined

[30] St Mark's Hospital,undefined

[31] National Institute of Immunology,undefined

[32] University of Delhi South Campus,undefined

[33] University of Liverpool,undefined

[34] Manchester Centre for Genomic Medicine,undefined

[35] University of Manchester and Central Manchester University Hospitals National Health Service (NHS) Foundation Trust,undefined

[36] Dayanand Medical College and Hospital,undefined

[37] St. Mary's Hospital,undefined

[38] Asan Medical Center,undefined

[39] University of Ulsan College of Medicine,undefined

[40] Institute of Clinical Molecular Biology,undefined

[41] Christian-Albrechts-University of Kiel,undefined

[42] University of Groningen,undefined

[43] University Medical Center Groningen,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

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学科分类号：

摘要：

Rinse Weersma, Carl Anderson and colleagues report the results of a trans-ancestry association study of inflammatory bowel disease. They implicate 38 new susceptibility loci, and show that the variance explained by each IBD risk locus is consistent across diverse ancestries, with a few notable exceptions.

引用

页码：979 / 986

页数：7

共 90 条

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