Relationship between body-mass index and serum folate concentrations in pregnant women

被引：0
作者：
H Kim
J-Y Hwang
K-N Kim
E-H Ha
H Park
M Ha
K-Y Lee
Y-C Hong
T Tamura
N Chang
机构：
[1] Ewha Wom,Department of Nutritional Science and Food Management
[2] a,Department of Preventive Medicine
[3] ns University,Department of Preventive Medicine
[4] Graduate School of Education,Department of Pediatrics
[5] Sangmyung University,Department of Preventive Medicine
[6] College of Medicine,undefined
[7] Ewha Wom,undefined
[8] an,undefined
[9] s University,undefined
[10] Dankook University College of Medicine,undefined
[11] Ulsan University Hospital,undefined
[12] Ulsan University College of Medicine,undefined
[13] Seoul National University College of Medicine,undefined
来源：
European Journal of Clinical Nutrition | 2012年 / 66卷
关键词：
folate; serum; body-mass index; pregnancy; human; malformations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.
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页码：136 / 138
页数：2
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