A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

被引：0

作者：

Michael St. Andre

Mark Johnson

Prashant N. Bansal

Jeremy Wellen

Andrew Robertson

Alan Opsahl

Peter M. Burch

Peter Bialek

Carl Morris

Jane Owens

机构：

[1] Pfizer Inc.,Rare Disease Research Unit

[2] Boston University School of Medicine,NIGMS Training Program in Biomolecular Pharmacology, Department of Pharmacology & Experimental Therapeutics

[3] Pfizer Inc.,Early Clinical Development

[4] Pfizer Inc.,Investigative Pathology

[5] Pfizer Inc.,Research and Development Drug Safety

[6] Present Address: PAREXEL Informatics,undefined

[7] Present Address: Summit Therapeutics,undefined

[8] Present Address: Solid Biosciences,undefined

[9] Present Address: Proteostasis Therapeutics,undefined

来源：

Skeletal Muscle | / 7卷

关键词：

Myostatin; Hypertrophy; Skeletal muscle; Duchenne muscular dystrophy; Monoclonal antibody; mdx;

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