A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

被引：0

作者：

Michael St. Andre

Mark Johnson

Prashant N. Bansal

Jeremy Wellen

Andrew Robertson

Alan Opsahl

Peter M. Burch

Peter Bialek

Carl Morris

Jane Owens

机构：

[1] Pfizer Inc.,Rare Disease Research Unit

[2] Boston University School of Medicine,NIGMS Training Program in Biomolecular Pharmacology, Department of Pharmacology & Experimental Therapeutics

[3] Pfizer Inc.,Early Clinical Development

[4] Pfizer Inc.,Investigative Pathology

[5] Pfizer Inc.,Research and Development Drug Safety

[6] Present Address: PAREXEL Informatics,undefined

[7] Present Address: Summit Therapeutics,undefined

[8] Present Address: Solid Biosciences,undefined

[9] Present Address: Proteostasis Therapeutics,undefined

来源：

Skeletal Muscle | / 7卷

关键词：

Myostatin; Hypertrophy; Skeletal muscle; Duchenne muscular dystrophy; Monoclonal antibody; mdx;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 113 条

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[2] Finkel R(2013)Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy PLoS One 8 e81302-2414
[3] Birnkrant DJ(2006)Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects Exp Cell Res 312 2401-151
[4] Case LE(2007)A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs PLoS Genet 3 e79-1192
[5] Clemens PR(2011)The role of myostatin in muscle wasting: an overview J Cachexia Sarcopenia Muscle 2 143-421
[6] Cripe L(1984)Chromosome-linked muscular dystrophy (mdx) in the mouse Proc Natl Acad Sci U S A 81 1189-549
[7] Finkel RS(2002)Functional improvement of dystrophic muscle by myostatin blockade Nature 420 418-971
[8] Flanigan KM(2005)Myostatin propeptide-mediated amelioration of dystrophic pathophysiology FASEB J 19 543-1297
[9] Wong B(2003)Inhibition of myostatin in adult mice increases skeletal muscle mass and strength Biochem Biophys Res Commun 300 965-1318
[10] Bonnemann C(2011)Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy Am J Pathol 178 1287-707