Multi-gene signatures in breast cancer: actual clinical impact

被引：0
作者：
Simon P. Gampenrieder
Gabriel Rinnerthaler
Richard Greil
机构：
[1] Paracelsus Medical University Salzburg,IIIrd Medical department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute with Laboratory of Immunological and Molecular Can
来源：
memo - Magazine of European Medical Oncology | 2014年 / 7卷 / 1期
关键词：
Breast cancer; Molecular pathology; Intrinsic subtypes; Gene expression; Prognostic; Predictive;
D O I：
10.1007/s12254-014-0130-3
中图分类号：
学科分类号：
摘要：
The molecular pathology has fundamentally modified our understanding of breast cancer. Today, breast cancer is understood as a heterogeneous disease consisting of at least five different subtypes. These subtypes show specific mRNA levels and somatic alterations and derive probably from different precursor cells. Multi-gene signatures enable us not only to differentiate these subtypes but also to define different risk groups for relapse after primary treatment. The clinical impact of these signatures is critically discussed in this review.
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页码：16 / 21
页数：5
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