High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma

[1] Gao T(2005)PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth Mol Cell 18 13-24

[2] Furnari F(2014)PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice Gastroenterology 146 1301-12

[3] Newton AC(2001)Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res 61 3986-97

[4] Li X(2002)Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants Cell Death Differ 9 893-904

[5] Stevens PD(2012)Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL) Leukemia 26 1689-92

[6] Liu J(2012)PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma Oncogene 31 1264-74

[7] Yang H(2009)Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis Oncogene 28 994-1004

[8] Wang W(2013)The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer Oncogene 32 471-8

[9] Wang C(2011)Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression Cancer Cell 20 173-86

[10] Brognard J(2013)Loss expression of PHLPP1 correlates with lymph node metastasis and exhibits a poor prognosis in patients with gastric cancer J Surg Oncol 108 427-32

[1] Gao T(2005)PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth Mol Cell 18 13-24

[2] Furnari F(2014)PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice Gastroenterology 146 1301-12

[3] Newton AC(2001)Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res 61 3986-97

[4] Li X(2002)Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants Cell Death Differ 9 893-904

[5] Stevens PD(2012)Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL) Leukemia 26 1689-92

[6] Liu J(2012)PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma Oncogene 31 1264-74

[7] Yang H(2009)Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis Oncogene 28 994-1004

[8] Wang W(2013)The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer Oncogene 32 471-8

[9] Wang C(2011)Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression Cancer Cell 20 173-86

[10] Brognard J(2013)Loss expression of PHLPP1 correlates with lymph node metastasis and exhibits a poor prognosis in patients with gastric cancer J Surg Oncol 108 427-32