PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

被引：0
|
作者：
Tamara Berdyyeva
Chunfang Xia
Natalie Taylor
Yingbo He
Gang Chen
Chaofeng Huang
Wei Zhang
Hartmuth Kolb
Michael Letavic
Anindya Bhattacharya
Anna Katrin Szardenings
机构：
[1] Janssen Research & Development LLC,
来源：
Molecular Imaging and Biology | 2019年 / 21卷
关键词：
P2X7 receptor; Neuroinflammation; Positron emission tomography (PET); PET imaging; [; F]JNJ-64413739; Lipopolysaccharide; LPS; Rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：871 / 878
页数：7
相关论文
共 50 条
  • [41] Synthesis of a novel neuroinflammation PET imaging agent ([18F]FM-PBR28) and its biological evaluations in rat models.
    Moon, Byung Seok
    Park, Chansoo
    Jung, Jae Ho
    Lee, Youn Woo
    Lee, Ho-Young
    Chi, Dae Yoon
    Lee, Byung Chul
    Kim, Sang Eun
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2013, 56 : S76 - S76
  • [42] Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
    Obada M. Alzghool
    Richard Aarnio
    Jatta S. Helin
    Saara Wahlroos
    Thomas Keller
    Markus Matilainen
    Junel Solis
    Jonathan J. Danon
    Michael Kassiou
    Anniina Snellman
    Olof Solin
    Juha O. Rinne
    Merja Haaparanta-Solin
    EJNMMI Research, 14
  • [43] Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
    Alzghool, Obada M.
    Aarnio, Richard
    Helin, Jatta S.
    Wahlroos, Saara
    Keller, Thomas
    Matilainen, Markus
    Solis, Junel
    Danon, Jonathan J.
    Kassiou, Michael
    Snellman, Anniina
    Solin, Olof
    Rinne, Juha O.
    Haaparanta-Solin, Merja
    EJNMMI RESEARCH, 2024, 14 (01)
  • [44] Preclinical Incorporation Dosimetry of [18F]FLUDA - a novel 18F-labeled tracer for PET imaging of the expression of the adenosine A2A receptor (A2AR)
    Sattler, Bernhard
    Kranz, Mathias
    Lai, Thu Hang
    Guendel, Daniel
    Toussaint, Magali
    Schroeder, Susann
    Moldovan, Rares-Petru
    Deuther-Conrad, Winnie
    Teodoro, Rodrigo
    Sabri, Osama
    Brust, Peter
    JOURNAL OF NUCLEAR MEDICINE, 2020, 61
  • [45] 2-[18F]Fludarabine, a Novel Positron Emission Tomography (PET) Tracer for Imaging Lymphoma: a Micro-PET Study in Murine Models
    Dhilly, Martine
    Guillouet, Stephane
    Patin, Delphine
    Fillesoye, Fabien
    Abbas, Ahmed
    Gourand, Fabienne
    Tirel, Olivier
    Galateau, Francoise
    MacKenzie, Eric T.
    Dumontet, Charles
    Leporrier, Michel
    Barre, Louisa
    MOLECULAR IMAGING AND BIOLOGY, 2014, 16 (01) : 118 - 126
  • [46] Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation
    Janssen, Bieneke
    Vugts, Danielle J.
    Funke, Uta
    Spaans, Arnold
    Schuit, Robert C.
    Kooijman, Esther
    Rongen, Marissa
    Perk, Lars R.
    Lammertsma, Adriaan A.
    Windhorst, Albert D.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2014, 57 (08): : 509 - 516
  • [47] 2-[18F]Fludarabine, a Novel Positron Emission Tomography (PET) Tracer for Imaging Lymphoma: a Micro-PET Study in Murine Models
    Martine Dhilly
    Stéphane Guillouet
    Delphine patin
    Fabien Fillesoye
    Ahmed Abbas
    Fabienne Gourand
    Olivier Tirel
    Françoise Galateau
    Eric T. MacKenzie
    Charles Dumontet
    Michel Leporrier
    Louisa Barré
    Molecular Imaging and Biology, 2014, 16 : 118 - 126
  • [48] Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
    Ory, Dieter
    Celen, Sofie
    Gijsbers, Rik
    Van Den Haute, Chris
    Postnov, Andrey
    Koole, Michel
    Vandeputte, Caroline
    Andres, Jose-Ignacio
    Alcazar, Jesus
    De Angelis, Med
    Langlois, Xavier
    Bhattacharya, Anindya
    Schmidt, Mark
    Letavic, Michael A.
    Vanduffel, Wim
    Van Laere, Koen
    Verbruggen, Alfons
    Debyser, Zeger
    Bormans, Guy
    JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (09) : 1436 - 1441
  • [49] Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging
    Liu, Qinghua
    Pan, Donghui
    Cheng, Chao
    Zhang, Dazhi
    Zhang, Anyu
    Wang, Lizhen
    Jiang, Hongdie
    Wang, Tao
    Liu, Hongrui
    Xu, Yuping
    Yang, Runlin
    Chen, Fei
    Yang, Min
    Zuo, Changjing
    PLOS ONE, 2015, 10 (11):
  • [50] Imaging of cerebral tryptophan metabolism using 7-[18F]FTrp-PET in a unilateral Parkinsonian rat model
    Endepols, Heike
    Zlatopolskiy, Boris D.
    Zischler, Johannes
    Alavinejad, Nazanin
    Apetz, Nadine
    Vus, Stefanie
    Drzezga, Alexander
    Neumaier, Bernd
    NEUROIMAGE, 2022, 247
12345