The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

被引：0
作者：
Monique van Abel
Joost G. J. Hoenderop
René J. M. Bindels
机构：
[1] Radboud University Nijmegen Medical Centre,Department of Physiology, Nijmegen Centre for Molecular Life Sciences
[2] Radboud University Nijmegen Medical Centre,160 Cell Physiology
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2005年 / 371卷
关键词：
ECaC; Kidney; Intestine; Active Ca; transport; Vitamin D; Estrogen; Parathyroid hormone; Channel (in)activation;
D O I：
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学科分类号：
摘要：
The epithelial Ca2+ channels TRPV5 and TRPV6 represent a new family of Ca2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca2+ entry mechanism in active Ca2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca2+ (re)absorption makes it a prime target for regulation to maintain Ca2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca2+ channels.
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页码：295 / 306
页数：11
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