Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children

被引：0

作者：

Peter Holmquist

O. Torffvit

Per E. Jørgensen

Niels Tørring

Ebba Nexø

Sture Sjöblad

机构：

[1] Department of Pediatrics,

[2] University Hospital Lund,undefined

[3] Sweden,undefined

[4] Department of Medicine,undefined

[5] University Hospital Lund,undefined

[6] 221 85 Lund,undefined

[7] Sweden e-mail: Ole.Torffvit@med.lu.se Tel.: +46-46-2220702,undefined

[8] Fax: +46-46-2110908,undefined

[9] Department of Clinical Biochemistry,undefined

[10] Viborg-Kjellerup County Hospital,undefined

[11] Denmark,undefined

[12] Department of Clinical Biochemistry,undefined

[13] AKH Aarhus University Hospital,undefined

[14] Denmark,undefined

来源：

Pediatric Nephrology | 2001年 / 16卷

关键词：

Keywords Albuminuria; Diabetes; Epidermal growth factor; Ketonuria; Tamm-Horsfall protein; Tubules;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Both glomerular and tubular markers have been used to follow diabetic nephropathy. However, neither albumin nor proximal tubular markers have proven useful in prepubertal diabetes. Hence we studied two markers derived from the distal tubular cells, Tamm-Horsfall protein (THP) and epidermal growth factor (EGF). The urinary excretion of THP and EGF was examined in samples obtained during the first 20 days and 1 year after diagnosis of diabetes in children aged 4–15 years. Fourteen children without and 18 with ketonuria were examined, and 17 age-matched healthy children participated as controls. The excretion rate of EGF was increased at diagnosis, while that of THP was not. After 20 days of treatment the excretion of EGF had normalized, while the excretion of THP was decreased. Similar results were obtained after 1 year. In conclusion, in spite of good metabolic control a reduced excretion of THP persisted for at least 1 year after the diagnosis of diabetes. Whether the finding of reduced excretion of THP has any biological significance awaits further study.

引用

页码：488 / 492

页数：4