Early Graft Dysfunction in Living Donor Liver Transplantation and the Small-for-size Syndrome

被引:2
作者
Graham J.A. [1 ]
Samstein B. [1 ]
Emond J.C. [1 ,2 ]
机构
[1] Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, 10032, NY
[2] Transplant Services, Columbia University and The New York Presbyterian Hospital, 622 W. 168th St., New York, 10032, NY
关键词
Early graft dysfunction; Liver; Living donor; Portal hypertension; Small-for-size syndrome; Transplantation;
D O I
10.1007/s40472-013-0006-1
中图分类号
学科分类号
摘要
Living donor liver transplantation (LDLT) has arisen as a viable means to reduce waitlist mortality. However, its widespread embrace by the liver transplant community has been met with frustration, centered on donor morbidity and small-for-size syndrome. Focusing on the latter entity, we describe the initial recognition of this early graft dysfunction, the theorized pathophysiology and solutions to remedy its emergence. © 2014, Springer International Publishing AG.
引用
收藏
页码:43 / 52
页数:9
相关论文
共 95 条
[1]  
Broelsch C.E., Whitington P.F., Emond J.C., Heffron T.G., Thistlethwaite J.R., Stevens L., Et al., Liver transplantation in children from living related donors. Surgical techniques and results, Ann Surg, 214, 4, pp. 428-437, (1991)
[2]  
Emond J.C., Clinical application of liver-related liver transplantation, Gastroenterol Clin North Am, 22, 2, pp. 301-315, (1993)
[3]  
Dazzi A., Lauro A., Di Benedetto F., Masetti M., Cautero N., De Ruvo N., Et al., Living donor liver transplantation in adult patients: our experience, Transplant Proc, 37, 6, pp. 2595-2596, (2005)
[4]  
Dahm F., Georgiev P., Clavien P.A., Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications, Am J Transplant, 5, 11, pp. 2605-2610, (2005)
[5]  
Chan S.C., Lo C.M., Ng K.K., Fan S.T., Alleviating the burden of small-for-size graft in right liver living donor liver transplantation through accumulation of experience, Am J Transplant, 10, 4, pp. 859-867, (2010)
[6]  
Yamaoka Y., Washida M., Honda K., Tanaka K., Mori K., Shimahara Y., Et al., Liver transplantation using a right lobe graft from a living related donor, Transplantation, 57, 7, pp. 1127-1130, (1994)
[7]  
Wachs M.E., Bak T.E., Karrer F.M., Everson G.T., Shrestha R., Trouillot T.E., Et al., Adult living donor liver transplantation using a right hepatic lobe, Transplantation, 66, 10, pp. 1313-1316, (1998)
[8]  
Marcos A., Fisher R.A., Ham J.M., Olzinski A.T., Shiffman M.L., Sanyal A.J., Et al., Selection and outcome of living donors for adult to adult right lobe transplantation, Transplantation, 69, 11, pp. 2410-2415, (2000)
[9]  
Fan S.T., Lo C.M., Liu C.L., Yong B.H., Chan J.K., Ng I.O., Safety of donors in live donor liver transplantation using right lobe grafts, Arch Surg, 135, 3, pp. 336-340, (2000)
[10]  
Berg C.L., Merion R.M., Shearon T.H., Olthoff K.M., Brown R.S., Baker T.B., Et al., Liver transplant recipient survival benefit with living donation in the model for endstage liver disease allocation era, Hepatology, 54, 4, pp. 1313-1321, (2011)