Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged

被引：0
作者：
Abbe N. Vallejo
机构：
[1] University of Pittsburgh School of Medicine,Departments of Pediatrics and Immunology
[2] Children's Hospital of Pittsburgh Rangos,Division of Rheumatology
[3] the Mniversity of Pittsburgh Cancer Institute,undefined
[4] the McGowan Institute for Regenerative Medicine,undefined
来源：
Immunologic Research | 2006年 / 36卷
关键词：
Aging; Replicative senescence; T cell repertoire; Telomere;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aging immune system is characterized by the contraction of T cell receptor (TCR) diversity and the de novo expression of NK-related receptors (NKR) on oligoclonal T cells. NKR+T cells likely represent a secondary immune diversification as a biological adaptation of aging to ensure host defense despite shrinkage of the TCR repertoire. NKRs are expressed in various combinations even among TCR-identical cells, and are capable of triggering effector pathways in either TCR-independent or TCR-dependent fashion. Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly.
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页码：221 / 228
页数：7
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