Critical review of SPECT imaging in pulmonary embolism

被引:6
作者
Stein P.D. [1 ,3 ]
Sostman H.D. [2 ]
Matta F. [1 ]
机构
[1] Department of Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, MI
[2] Department of Radiology, Weill Cornell Medical College, New York, NY
[3] Michigan State University College of Osteopathic Medicine, 4707 St Antoine, Box 402, Detroit, 48201, MI
关键词
Pulmonary embolism; Single-photon emission computed tomography; Venous thromboembolism;
D O I
10.1007/s40336-014-0079-6
中图分类号
学科分类号
摘要
Outcome studies have shown that pulmonary embolism can be safely excluded in patients with negative ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT). The effective radiation dose of V/Q SPECT is much less than with computed tomographic (CT) pulmonary angiography, which would make it preferable to CT angiography in many young female patients. The accuracy of V/Q SPECT, however, is difficult to assess, because most published investigations are limited by incorporation bias or partial verification bias, as well as other limitations in study design and reporting. Consequently, the accuracy of V/Q SPECT relative to planar V/Q scintigraphy or CT angiography has not been definitively determined. There is need for a prospective investigation of the accuracy of V/Q SPECT with consecutive patients, blinded interpretations, and an independent reference standard, or independent composite reference standard. © 2014, Italian Association of Nuclear Medicine and Molecular Imaging.
引用
收藏
页码:379 / 390
页数:11
相关论文
共 60 条
[1]  
PIOPED Investigators, Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED), J Am Med Assoc, 263, pp. 2753-2759, (1990)
[2]  
Stein P.D., Kayali F., Olson R.E., Trends in the use of diagnostic imaging in patients hospitalized with acute pulmonary embolism, Am J Cardiol, 93, pp. 1316-1317, (2004)
[3]  
Stein P.D., Freeman L.M., Sostman H.D., Et al., Single photon emission computed tomography (SPECT) in acute pulmonary embolism, J Nucl Med, 50, pp. 1999-2007, (2009)
[4]  
Bajc M., Neilly J.B., Miniati M., Et al., EANM guidelines for ventilation/perfusion scintigraphy. Part 1. Pulmonary imaging with ventilation/perfusion single photon emission tomography, Eur J Nucl Med Mol Imaging, 36, pp. 1356-1370, (2009)
[5]  
Parker J.A., Coleman R.E., Grady E., Et al., SNM practice guideline for lung scintigraphy 4.0*, J Nucl Med Technol, 40, pp. 57-65, (2012)
[6]  
Miniati M., Pistolesi M., Marini C., Et al., Value of perfusion lung scan in the diagnosis of pulmonary embolism. results of the Prospective Investigative Study of Acute Pulmonary Embolism (PISA-PED), Am J Resp Crit Care Med, 154, pp. 1387-1393, (1996)
[7]  
Gottschalk A., Sostman H.D., Coleman R.E., Et al., Ventilation-perfusion scintigraphy in the PIOPED study. Part II. Evaluation of the scintigraphic criteria and interpretations, J Nucl Med, 34, pp. 1119-1126, (1993)
[8]  
Sostman H.D., Miniati M., Gottschalk A., Et al., Sensitivity and specificity of perfusion scintigraphy combined with chest radiography for diagnosing pulmonary embolism, J Nucl Med, 49, pp. 1741-1748, (2008)
[9]  
International Commission on Radiological Protection ICRP I.C.R.P., Radiation dose to patients from radiopharmaceuticals (addendum 2 to ICRP 53) ICRP publication 80, Ann ICRP, 28, pp. 1-126, (1998)
[10]  
Beadsmoore C., Cheow H.K., Szczepura K., Et al., Healthy passive cigarette smokers have increased pulmonary alveolar permeability, Nucl Med Commun, 28, pp. 75-77, (2007)