Genetic Diagnosis of Inborn Errors of Immunity in an Emerging Country: a Retrospective Study of 216 Moroccan Patients

被引:0
作者
Abderrahmane Moundir
Hind Ouair
Ibtihal Benhsaien
Leila Jeddane
Nouredine Rada
Naïma Amenzoui
Zineb Jouhadi
Fatima Adnane
Naïma El Hafidi
Amina Kili
Asmaa Bourhanbour Drissi
Abdeladim Babakhouya
Sarra Benmiloud
Mohamed Hbibi
Noufissa Benajiba
Mustapha Hida
Mohamed Bouskraoui
Chafiq Mahraoui
Brahim Admou
Jalila El Bakkouri
Fatima Ailal
Ahmed Aziz Bousfiha
机构
[1] Hassan II University,Clinical Immunology, Inflammation and Allergy Laboratory (LICIA), Faculty of Medicine and Pharmacy
[2] A. Harouchi Children Hospital,Department of Pediatric Infectious Diseases and Clinical Immunology
[3] Ibn Rochd University Hospital,Department of Pediatric Infectious Diseases
[4] Laboratoire National de Référence,Department of Pediatric Infectious Diseases
[5] Mohamed VI University of Health Sciences,Department of Pediatric Hemato
[6] Mohammed VI University Hospital,Oncology
[7] Ibn Sina University Hospital,Immunology Laboratory
[8] Ibn Sina University Hospital,Department of Pediatric Infectious Diseases
[9] Ibn Rochd University Hospital,Department of Pediatrics
[10] Hassan II University Hospital,Pneumo
[11] Mohammed VI University Hospital,Allergology Unit, Rabat Children Hospital
[12] Faculty of Medicine,Immunology Laboratory
[13] Mohammed V University,undefined
[14] Mohammed VI University Hospital,undefined
来源
Journal of Clinical Immunology | 2023年 / 43卷
关键词
Inborn errors of immunity; Primary immunodeficiencies; Genetic defects; Moleculardiagnosis; Genetic testing; Morocco;
D O I
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中图分类号
学科分类号
摘要
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页码:485 / 494
页数:9
相关论文
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[1]  
Tangye SG(2022)Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee J Clin Immunol 24 1-35
[2]  
Al-Herz W(2021)The ever-increasing array of novel inborn errors of immunity: an interim update by the IUIS committee J Clin Immunol 41 666-679
[3]  
Bousfiha A(2020)The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity? Hum Genet 139 681-694
[4]  
Tangye SG(2014)A general framework for estimating the relative pathogenicity of human genetic variants Nat Genet 46 310-315
[5]  
Al-Herz W(2016)The mutation significance cutoff: gene-level thresholds for variant predictions Nat Methods 13 109-110
[6]  
Bousfiha A(2019)Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis Nat Med 25 1873-1884
[7]  
Casanova JL(2020)Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria Cell 183 1826-1847.e31
[8]  
Abel L(2018)Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency Nat Immunol 19 973-985
[9]  
Kircher M(2015)Human TYK2 deficiency: mycobacterial and viral infections without hyper-IgE syndrome J Exp Med 212 1641-1662
[10]  
Witten DM(2016)Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations J Exp Med 213 2413-2435