Evaluation of flavonoids from Zostera asiatica as antioxidants and nitric oxide inhibitors

被引：0
作者：
Hojun Kim
Huijeong Jeong
Joo Wan Hong
Eunshin Ju
Chang-Suk Kong
Youngwan Seo
机构：
[1] Korea Maritime and Ocean University,Division of Marine Bioscience, College of Ocean Science and Technology
[2] Korea Maritime and Ocean University,Department of Convergence Study on the Ocean Science and Technology, Ocean Science and Technology School
[3] Silla University,Department of Food and Nutrition, College of Medical and Life Sciences
[4] Silla University,Marine Biotechnology Center for Pharmaceuticals and Foods
来源：
Biotechnology and Bioprocess Engineering | 2016年 / 21卷
关键词：
antioxidant; flavonoid; luteolin 3’-sulfate; scavenging effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Zostera asiatica is one of the five members of the genus Zostera that can be found in Korea. Studies have reported the phytochemical properties and bioactivities of Zostera species. Current study focused on the antioxidant effects of Z. asiatica as a part of ongoing research for bioactive substances from marine resources. Results indicated that a crude extract of Z. asiatica not only scavenged on peroxynitrite in vitro and on intracellular reactive oxygen species (ROS) but also inhibited production of nitric oxide (NO). The crude extract was subjected to solvent fractionation for bioactivity-based separation using aforementioned three bioassay systems. From the active n-butanol fraction, two flavonoids were isolated and characterized as luteolin (1) and luteolin-3’-sulfate (2). Both flavonoids showed significant antioxidant effects. In conclusion, Z. asiatica was demonstrated to possess antioxidant effect partly attributed to isolated flavonoids, the first such effect reported from Z. asiatica, to the best of our knowledge.
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页码：823 / 829
页数：6
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  • [1] Berlett B. S.(1997)Protein oxidation in aging, disease, and oxidative stress J. Biol. Chem. 272 20313-20316
  • [2] Stadtman E. R.(2003)Antioxidant nutrients and chronic disease: Use of biomarkers of exposure and oxidative stress status in epidemiologic research J. Nutr. 133 933-59
  • [3] Mayne S. T.(2012)Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy Cardiovasc. Ther. 30 49-219
  • [4] Elmarakby A. A.(2008)Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease Verh. K. Acad. Geneeskd. Belg. 70 193-80
  • [5] Sullivan J. C.(2009)Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer Recent Pat. Inflamm. Allergy Drug Discov. 3 73-230
  • [6] Holvoet P.(2000)Mitochondrial free radical generation, oxidative stress, and aging Free Radical Biol. Med. 29 222-277
  • [7] Khansari N.(1996)Inflammation, free radicals, and antioxidants Nutrition 12 274-3833
  • [8] Shakiba Y.(2004)Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities Curr. Pharm. Des. 10 3813-442
  • [9] Mahmoudi M.(2006)Antioxidants and inflammatory disease: Synthetic and natural antioxidants with anti-inflammatory activity Comb. Chem. High Throughput Screen. 9 425-83
  • [10] Cadenas E.(2010)Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms Arch. Dermatol. Res. 302 71-66
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