Induction of UDP-Glucuronosyltransferase UGT1A1 by the Flavonoid Chrysin in Caco-2 Cells—Potential Role in Carcinogen Bioinactivation

被引：0
作者：
Alema Galijatovic
Yoko Otake
U. Kristina Walle
Thomas Walle
机构：
[1] Medical University of South Carolina,Department of Cell and Molecular Pharmacology and Experimental Therapeutics
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
flavonoids; chrysin; enzyme induction; glucuronidation; UDP-glucuronosyltransferase; UGT1A1; intestinal cells; Caco-2 cells;
D O I：
暂无
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学科分类号：
摘要：
Purpose. Dietary flavonoids, present in fruits, vegetables and beverages have been demonstrated to be protective in cancer. Recently, we showed that the flavonoid chrysin induced UDP-glucuronosyl- transferase (UGT) activity and expression in the human intestinal cell line Caco-2. In the present study, we determined the specific UGT isoform(s) induced and whether this induction facilitates glucuronidation and potential detoxification of the colon carcinogen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-hydroxy-PhIP).
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页码：374 / 379
页数：5
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