Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Aleman C(2003)P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential Cancer Res 63 3084-3091

Annereau JP(2005)Interactions between antiretrovirals and antineoplastic drug therapy Clin Pharmacokinet 44 111-145

Liang XJ(2011)Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model Am J Pathol 178 838-852

Cardarelli CO(2008)Repositioning HIV protease inhibitors as cancer therapeutics Curr Opin HIV AIDS 3 666-675

Taylor B(2010)Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines J Antimicrob Chemother 65 1672-1680

Yin JJ(2002)AIDS-related malignancies Nat Rev Cancer 2 373-382

Aszalos A(2008)British HIV Association guidelines for HIV-associated malignancies 2008 HIV Med 9 336-388

Gottesman MM(2008)Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer J Clin Oncol 26 2699-2706

Antoniou T(2008)P-glycoprotein: so many ways to turn it on J Clin Pharmacol 48 365-378

Tseng AL(2008)Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma Cancer Res 68 8361-8368

Aleman C(2003)P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential Cancer Res 63 3084-3091

Annereau JP(2005)Interactions between antiretrovirals and antineoplastic drug therapy Clin Pharmacokinet 44 111-145

Liang XJ(2011)Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model Am J Pathol 178 838-852

Cardarelli CO(2008)Repositioning HIV protease inhibitors as cancer therapeutics Curr Opin HIV AIDS 3 666-675

Taylor B(2010)Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines J Antimicrob Chemother 65 1672-1680

Yin JJ(2002)AIDS-related malignancies Nat Rev Cancer 2 373-382

Aszalos A(2008)British HIV Association guidelines for HIV-associated malignancies 2008 HIV Med 9 336-388

Gottesman MM(2008)Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer J Clin Oncol 26 2699-2706

Antoniou T(2008)P-glycoprotein: so many ways to turn it on J Clin Pharmacol 48 365-378

Tseng AL(2008)Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma Cancer Res 68 8361-8368