Contribution of Ryanodine Receptors in Forming Presynaptic Ca2+ Level and Cholinergic Modulation in Response to Single Potential in Frog Neuromuscular Junction

被引：0
作者：
Khaziev E. [1 ,2 ,3 ]
Bukharaeva E. [1 ,2 ]
Nikolsky E. [1 ,2 ,4 ]
Samigullin D. [1 ,2 ,3 ]
机构：
[1] Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, 2/31 Lobachevsky str, Kazan
[2] Kazan Federal University, 17 Kremlevskaya str, Kazan
[3] National Research Technical University named after A.N.Tupolev, 31/7 K. Marx str, Kazan
[4] Kazan State Medical University, 49 Butlerov str, Kazan
来源：
BioNanoScience | 2017年 / 7卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
Ca[!sup]2+[!/sup] transient; Calcium; Frog; Neuromuscular junction; Ryanodine; Ryanodine receptors; Synapse;
D O I：
10.1007/s12668-016-0308-8
中图分类号：
学科分类号：
摘要：
Ca2+ entering through voltage-gated Ca2+ channels plays a key role in the initiation of neurotransmitter secretion. However, intracellular Ca2+ storages such as endoplasmic reticulum (ER) can also contribute in the presynaptic Ca2+ level forming. Also ryanodine-dependent Ca2+-induced Ca2+ channels of endoplasmic reticulum may contribute in secretion inhibiting action of cholinomimetics. In this work, we use a photometric method for estimating the relative change in the level of presynaptic Ca2+ ions (Ca2+ transient). We have shown that during low-frequency stimulation Ca2+ release from the ER is involved in forming of presynaptic Ca2+ level. And more likely those effects of the cholinomimetics on Ca2+ transient are not related to Ca2+ release from the endoplasmic reticulum. © 2016, Springer Science+Business Media New York.
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页码：106 / 108
页数：2
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