The role of the orphan nuclear receptor COUP-TFII in tumorigenesis

被引：0
作者：
Mafei Xu
Jun Qin
Sophia Y Tsai
Ming-jer Tsai
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
[2] Institute of Health Sciences,undefined
[3] Shanghai Institutes for Biological Sciences,undefined
[4] Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine,undefined
来源：
Acta Pharmacologica Sinica | 2015年 / 36卷
关键词：
nuclear receptor; COUP-TFII; tumorigenesis; prostate cancer; breast cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms.
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页码：32 / 36
页数：4
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