Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair

被引：0
作者：
Yuan Fang
Yufang Zhang
Jianda Zhou
Ke Cao
机构：
[1] The Third Xiangya Hospital of Central South University,
[2] Anyang Tumor Hospital,undefined
来源：
Cell and Tissue Banking | 2019年 / 20卷
关键词：
Adipose-derived mesenchymal stem cell; Exosomes; Tissues repair mechanism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also abundant as they can be easily harvested with minimally invasive surgical techniques. This makes ADMSCs conducive for clinical applications. Recently, the secretory function of ADMSCs has been regarded as the primary mediator of MSC-based therapy. Exosomes are one kind of small cell extracellular membrane vesicles, which are primarily used to deliver cell-specific proteins, as well as nucleic acids secreted by various cell types. This review will introduce and characterize exosomes-derived ADMSCs (ADMSCs-Exo) and look at new therapies and prospective, including the limitations and outlook for therapeutic strategy. We will describe the latest research progress on myocardial repair, neuroprotection and neurotrophic effects, hepatic repair, renal repair, cutaneous repair, regeneration and other aspects using these cells.
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页码：153 / 161
页数：8
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