Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity

被引:0
作者
Vincenzo Guarcello
Carmelo Blanquicett
Fardos N. M. Naguib
Mahmoud H. el Kouni
机构
[1] University of Alabama at Birmingham,Department of Pharmacology and Toxicology, Comprehensive Cancer Center, Center for AIDS Research
[2] Emory University,Department of Medicine, School of Medicine
来源
Cancer Chemotherapy and Pharmacology | 2008年 / 62卷
关键词
Thymidine phosphorylase; Promoter methylation; Expression; Regulation; Cancer cells;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:85 / 96
页数:11
相关论文
共 289 条
[1]  
Ashour OM(1995)Enhancement of 5-fluoro-2′-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside Cancer Res 55 1092-1098
[2]  
Naguib FN(2002)Housekeeping gene variability in normal and carcinomatous colorectal and liver tissues: applications in pharmacogenomic gene expression studies Anal Biochem 303 209-214
[3]  
Khalifa MM(2005)Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects Clin Cancer Res 11 8773-8781
[4]  
Abdel-Raheem MH(1976)A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding Anal Biochem 72 248-254
[5]  
Panzica RP(1998)Thymidine phosphorylase, 2-deoxy- Biochem J 334 1-8
[6]  
el Kouni MH(2006)-ribose and angiogenesis Alcohol Clin Exp Res 30 928-937
[7]  
Blanquicett C(1998)Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation Leukemia 12 845-859
[8]  
Johnson MR(1993)Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells Cancer Res 53 3687-3693
[9]  
Heslin M(1990)Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines J Natl Cancer Inst 82 4-6
[10]  
Diasio RB(1995)What is the evidence that tumors are angiogenesis dependent? J Pathol 176 183-190