The Mediating Role of Depressive Symptoms in the Association Between Food Insecurity and HIV Related Health Outcomes Among HIV–HCV Co-Infected People

被引：0
作者：
Wusiman Aibibula
Joseph Cox
Anne-Marie Hamelin
Marina B. Klein
Paul Brassard
机构：
[1] McGill University,Department of Epidemiology, Biostatistics and Occupational Health
[2] CIUSSS du Centre-Est-de-L ‘Ile-de-Montréal,Public Health Department
[3] McGill University,Department of Medicine
[4] McGill University Health Centre,Division of Clinical Epidemiology
[5] Jewish General Hospital,Centre for Clinical Epidemiology
来源：
AIDS and Behavior | 2020年 / 24卷
关键词：
HIV–HCV co-infection; Food insecurity; HIV viral load; CD4 count; Mediation analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Food insecurity may lead to depressive symptoms, which are known to be associated with poor HIV related health outcomes. However, it is unclear to what extent food insecurity ‘directly’ affects these outcomes. We used data from the Food Security & HIV–HCV Sub-Study of the Canadian Co-Infection Cohort to assess the controlled direct effect. People experiencing severe food insecurity had 1.47 (95% CI 1.04–2.09) times the risk of having detectable HIV viral load and 0.94 (95% CI 0.87–1.02) fold change in CD4 count. After holding depressive symptoms constant, the association between severe food insecurity and HIV viral load was attenuated to a statistically non-significant level (RR 1.36, 95% CI: 0.95–1.96), whereas the association between severe food insecurity and CD4 count was unchanged. Depressive symptoms partially mediate the effect of severe food insecurity on HIV viral suppression; interventions focused on depressive symptoms alone may not be sufficient, however, to eliminate this effect.
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页码：2188 / 2194
页数：6
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