An ultrastructural study of calcifying odontogenic cyst, especially calcified material

被引：2

作者：

Mimura M. ^{[1
]}

Tanaka N. ^{[2
]}

Kimijima Y. ^{[3
]}

Ichinose S. ^{[4
]}

Sasaki K. ^{[1
]}

Amagasa T. ^{[1
]}

机构：

[1] Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549

[2] Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo

[3] Department of Oral and Maxillofacial Surgery, National Defense Medical College, Saitama

[4] Instrumental Analysis Research Center for Life Science, Tokyo Medical and Dental University, Tokyo

来源：

Medical Electron Microscopy | 2002年 / 35卷 / 2期

关键词：

Calcification; Calcifying odontogenic cyst; Ghost cell; Mitochondria; Tonofilament; Tonofilament bundles;

D O I：

10.1007/s007950200014

中图分类号：

学科分类号：

摘要：

The ultrastructural features of calcification in a case of calcifying odontogenic cyst (COC) were studied. Scanning electron microscopic examination of the inner parts of the cyst wall revealed many short microvilli, and X-ray microanalysis of the high-density masses in the intercellular parts showed prominent calcium peaks, which meant that these masses were calcified materials. On transmission electron microscopic observations, many calcifications exhibited a distinctive ring formation around the periphery of a central core that consisted of an amorphous structure. These calcifications were observed with necrotic remnants of nuclear material and many identifiable mitochondria, thin fibers, and epithelial cells. The cytoplasm of ghost cells consisted of numerous short electron-dense tonofilament bundles. Needle-like structures were shown in the tonofilament bundles. X-ray diffraction analysis showed that the needle-like crystals were hydroxyapatite. It is suggested that calcification in a COC may be related to degenerative mitochondria and tonofilament bundles of ghost cells.

引用

页码：109 / 116

页数：7

共 16 条

[1] Gorlin R.J., Pindborg J.J., Clausen F.P., Vickers R.A., The calcifying odontogenic cyst. A possible analogue of the cutaneous calcifying epithelioma of Malherbe. An analysis of 15 cases, Oral Surg Oral Med Oral Pathol, 15, pp. 1235-1243, (1962)
[2] Fejerskov O., Krogh J., The calcifying ghost cell odontogenic tumor or the calcifying odontogenic cyct, J Oral Pathol, 1, pp. 273-287, (1972)
[3] Buchner A., The central (intraosseous) calcifying odontogenic cyst: An analysis of 215 cases, J Oral Maxillofac Surg, 49, pp. 330-339, (1991)
[4] Freedman P.D., Lumerman H., Gee J.K., Calcifying odontogenic cyst. A review and analysis of 70 cases, Oral Surg Oral Med Oral Pathol, 40, pp. 93-106, (1975)
[5] Keszler A., Guglielmotti M.B., Calcifying odontogenic cyst associated with odontoma: Report of two cases, J Oral Maxillofac Surg, 45, pp. 457-459, (1987)
[6] Lello G.E., Makek M., Calcifying odontogenic cyst, Int J Oral Maxillofac Surg, 15, pp. 637-644, (1986)
[7] Mascres C., Donohue W.B., Vauclair R., The calcifying odontogenic cyst: Report of a case, J Oral Maxillofac Surg, 48, pp. 319-322, (1990)
[8] Praetorius F., Hjorting-Hansen E., Gorlin R.J., Vickers R.A., Calcifying odontogenic cyst. Range, variations and neoplastic potential, Acta Odontol Scand, 39, pp. 227-240, (1981)
[9] Kramer I.R.H., Pingdborg J.J., Shear M., Calcifying odontogenic cyst, Histological typing of odontogenic tumours, 2nd edn. WHO international histological classification of tumours, pp. 20-21, (1992)
[10] Snapp J.P., Gardner D.G., An ultrastructural study of the calcifications in calcifying odontogenic cysts and odontomas, Oral Surg Oral Med Oral Pathol, 44, pp. 757-766, (1977)

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