Endocrine role of bone in the regulation of energy metabolism

被引：0
作者：
Ruoyu Zhou
Qiaoyue Guo
Ye Xiao
Qi Guo
Yan Huang
Changjun Li
Xianghang Luo
机构：
[1] Xiangya Hospital of Central South University,Department of Endocrinology, Endocrinology Research Center
来源：
Bone Research | / 9卷
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摘要：
Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate local bone metabolism and metabolic functions. In addition, these factors can regulate global energy homeostasis by altering insulin sensitivity, feeding behavior, and adipocyte commitment. These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis, treatment, and prevention of metabolic diseases such as osteoporosis, obesity, and diabetes mellitus. In this review, we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.
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