Endocrine role of bone in the regulation of energy metabolism

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作者
Ruoyu Zhou
Qiaoyue Guo
Ye Xiao
Qi Guo
Yan Huang
Changjun Li
Xianghang Luo
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[1] Xiangya Hospital of Central South University,Department of Endocrinology, Endocrinology Research Center
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Bone Research | / 9卷
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摘要
Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate local bone metabolism and metabolic functions. In addition, these factors can regulate global energy homeostasis by altering insulin sensitivity, feeding behavior, and adipocyte commitment. These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis, treatment, and prevention of metabolic diseases such as osteoporosis, obesity, and diabetes mellitus. In this review, we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.
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[1]  
Sommerfeldt DW(2001)Biology of bone and how it orchestrates the form and function of the skeleton Eur. Spine J. 10 S86-S95
[2]  
Rubin CT(2001)Extracellular and intracellular regulation of calcium homeostasis Sci. World J. 1 919-925
[3]  
Bronner F(2011)Effects of the bone marrow microenvironment on hematopoietic malignancy Bone 48 115-120
[4]  
Askmyr M(2018)Modeling the human bone marrow niche in mice: from host bone marrow engraftment to bioengineering approaches J. Exp. Med. 215 729-743
[5]  
Quach J(2013)Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 Cell Metab. 17 901-915
[6]  
Purton LE(2006)Convergence between bone and energy homeostases: leptin regulation of bone mass Cell Metab. 4 341-348
[7]  
Abarrategi A(2017)Diabetes, bone and glucose-lowering agents: basic biology Diabetologia 60 1163-1169
[8]  
Kajimura D(2016)Fgf23 and parathyroid hormone signaling interact in kidney and bone Mol. Cell Endocrinol. 436 224-239
[9]  
Karsenty G(2017)DOK3 modulates bone remodeling by negatively regulating osteoclastogenesis and positively regulating osteoblastogenesis J. Bone Min. Res. 32 2207-2218
[10]  
Lecka-Czernik B(2015)Urokinase receptor mediates osteoclastogenesis via M-CSF release from osteoblasts and the c-Fms/PI3K/Akt/NF-κB pathway in osteoclasts J. Bone Min. Res. 30 379-388