Fluorinated γ-carbolines as a promising class of neuroprotective drugs

被引：0
作者：
A. A. Ustyugov
A. Yu. Aksinenko
D. A. Steinberg
M. A. Lapshina
V. O. Nebogatikov
S. O. Bachurin
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Chemical Bulletin | 2021年 / 70卷
关键词：
fluorinated γ-carbolines; amyotrophic lateral sclerosis; FUS protein;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A number of fluorinated γ-carboline derivatives were studied as potential agents that block the development of FUS protein aggregation, which underlies proteinopathy in amyotrophic lateral sclerosis. Compounds exhibiting high anti-aggregation potential against the FUS protein were identified by fluorescence microscopy. Lead compounds that reduce aggregation by a factor of two or more and have relatively low cytotoxicity were identified among the most active structures.
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页码：982 / 986
页数：4
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