Spectrum of p53 Tumor Suppressor Gene Mutations and Breast Cancer Survival

被引:0
作者
Hong Lai
Fangchao Ma
Edward Trapido
Lou Meng
Shenghan Lai
机构
[1] Johns Hopkins Medical Institutions,Department of Ophthalmology
[2] University of Miami School of Medicine,Department of Medicine
[3] and GRECC,Department of Epidemiology
[4] VA Medical Center,Department of Epidemiology
[5] University of Miami School of Medicine,undefined
[6] Dapeng-Metagene Biotechnology Co.,undefined
[7] Ltd.,undefined
[8] Johns Hopkins University Bloomberg School of Public Health,undefined
来源
Breast Cancer Research and Treatment | 2004年 / 83卷
关键词
breast cancer; p53 mutation; survival;
D O I
暂无
中图分类号
学科分类号
摘要
Context. p53 mutation is associated with poor prognosis in breast cancer patients. Mutations in different structural and functional domains of p53 have different effects on its biological activities. Nevertheless, few studies have examined the full spectrum of p53 gene mutations in relation to breast cancer survival.
引用
收藏
页码:57 / 66
页数:9
相关论文
共 186 条
[1]  
Harris CC(1996)p53: at the crossroads of molecular carcinogenesis and molecular epidemiology J Invest Dermatol Symp Proc 1 115-118
[2]  
Lane DP(1994)p53 and human cancers Br Med Bull 50 582-599
[3]  
Hollstein M(1991)p53 mutations in human cancers Science 253 49-53
[4]  
Sidransky D(1994)Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer Eur J Cancer 30A 175-180
[5]  
Vogelstein B(1992)pS2 expression in primary breast carcinomas: relationship to clinical and histological features and survival Breast Cancer Res Treat 21 111-119
[6]  
Harris CC(1993)Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer J Natl Cancer Inst 85 200-206
[7]  
Stenmark-Askmalm M(1993)Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis? Hum Pathol 24 469-476
[8]  
Stal O(1994)Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States J Natl Cancer Inst 86 705-712
[9]  
Sullivan S(1995)Usefulness of immunohistochemical staining for p53 in the prognosis of breast carcinomas: correlations with established prognosis parameters and with the proliferation marker, MIB-1 Gynecol Oncol 57 96-104
[10]  
Ferraud L(1998)Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: a prognostic factor in a large breast cancer cohort J Clin Oncol 16 2641-2650