Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data

被引:0
作者
R. L. Smith
T. Haslemo
H. Refsum
E. Molden
机构
[1] Diakonhjemmet Hospital,Center for Psychopharmacology
[2] University of Oslo,Department of Pharmaceutical Biosciences, School of Pharmacy
来源
European Journal of Clinical Pharmacology | 2016年 / 72卷
关键词
Valproic acid; Pharmacokinetics; Elderly; Gender; Pharmacogenetics;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1099 / 1104
页数:5
相关论文
共 177 条
[1]  
Lambert PA(1966)Neuropsychotropic action of a new anti-epileptic agent: depamide Ann Med Psychol (Paris) 124 707-710
[2]  
Carraz G(2013)Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder Cochrane Database Syst Rev 10 233-240
[3]  
Borselli S(1999)Population estimation of valproic acid clearance in adult patients using routine clinical pharmacokinetic data Biopharm Drug Dispos 20 205-216
[4]  
Carbel S(2008)Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review J Inherit Metab Dis 31 229-236
[5]  
Cipriani A(2009)Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10 Drug Metab Dispos 37 236-241
[6]  
Reid K(2013)Valproic acid pathway: pharmacokinetics and pharmacodynamics Pharmacogenet Genomics 23 13733-13738
[7]  
Young AH(1988)Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies J Biol Chem 263 261-271
[8]  
Macritchie K(2006)Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype Toxicol Sci 94 1395-1401
[9]  
Geddes J(2012)Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients Eur J Clin Pharmacol 68 665-669
[10]  
Blanco-Serrano B(1984)Pharmacokinetics of valproic acid in the elderly Br J Clin Pharmacol 17 697-700